Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Zeyu Lin; Joseph Cantone; Hao Lu; Beata Nowicka-Sans; Tricia Protack; Tian Yuan; Hong Yang; Zheng Liu; Dieter Drexler; Alicia Regueiro-Ren; Nicholas A. Meanwell; Mark Cockett; Mark Krystal; Max Lataillade; Ira B. Dicker

doi:10.1371/journal.ppat.1005990

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Open Access

Peer-reviewed

Research Article

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Zeyu Lin,

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Joseph Cantone,

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Hao Lu,

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Beata Nowicka-Sans †,

† Deceased.

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Tricia Protack,

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Tian Yuan,

Affiliation Discovery Chemistry Platforms, Princeton, New Jersey, United States of America
⨯
Hong Yang,

Affiliation Discovery Chemistry Platforms, Princeton, New Jersey, United States of America
⨯
Zheng Liu,

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Dieter Drexler,

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Alicia Regueiro-Ren,

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Nicholas A. Meanwell,

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Mark Cockett,

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Mark Krystal,

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Max Lataillade,

Affiliation Global Clinical Development, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯
Ira B. Dicker

* E-mail: Ira.B.Dicker@ViiVHealthcare.com, Iradicker@yahoo.com

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America
⨯

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

Zeyu Lin,
Joseph Cantone,
Hao Lu,
Beata Nowicka-Sans,
Tricia Protack,
Tian Yuan,
Hong Yang,
Zheng Liu,
Dieter Drexler,
Alicia Regueiro-Ren

Published: November 28, 2016
https://doi.org/10.1371/journal.ppat.1005990

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