Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth

S. Abigail Smith; Samantha L. Burton; William Kilembe; Shabir Lakhi; Etienne Karita; Matt Price; Susan Allen; Eric Hunter; Cynthia A. Derdeyn

doi:10.1371/journal.ppat.1005989

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Peer-reviewed

Research Article

Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth

S. Abigail Smith,

Affiliations Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America
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Samantha L. Burton,

Affiliations Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America
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William Kilembe,

Affiliation Zambia Emory HIV Research Project, Lusaka, Ndola and Kitwe, Zambia
⨯
Shabir Lakhi,

Affiliation Zambia Emory HIV Research Project, Lusaka, Ndola and Kitwe, Zambia
⨯
Etienne Karita,

Affiliation Projet San Francisco, Kigali, Rwanda
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Matt Price,

Affiliations International AIDS Vaccine Initiative (IAVI), New York, New York, United States of America, UCSF Department of Epidemiology and Biostatistics, San Francisco, California, United States of America

http://orcid.org/0000-0002-2918-1373

⨯
Susan Allen,

Affiliation Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America
⨯
Eric Hunter,

Affiliations Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America
⨯
Cynthia A. Derdeyn

* E-mail: cderdey@emory.edu

Affiliations Yerkes National Primate Research Center, Emory University Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory University Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University Atlanta, Georgia, United States of America
⨯

Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth

S. Abigail Smith,
Samantha L. Burton,
William Kilembe,
Shabir Lakhi,
Etienne Karita,
Matt Price,
Susan Allen,
Eric Hunter,
Cynthia A. Derdeyn

Published: November 16, 2016
https://doi.org/10.1371/journal.ppat.1005989

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Glycosylation
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