Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Huib H. Rabouw; Martijn A. Langereis; Robert C. M. Knaap; Tim J. Dalebout; Javier Canton; Isabel Sola; Luis Enjuanes; Peter J. Bredenbeek; Marjolein Kikkert; Raoul J. de Groot; Frank J. M. van Kuppeveld

doi:10.1371/journal.ppat.1005982

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Open Access

Peer-reviewed

Research Article

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Huib H. Rabouw,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Martijn A. Langereis ,

Contributed equally to this work with: Martijn A. Langereis, Robert C. M. Knaap

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Robert C. M. Knaap ,

Contributed equally to this work with: Martijn A. Langereis, Robert C. M. Knaap

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Tim J. Dalebout,

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

http://orcid.org/0000-0002-5916-7548

⨯
Javier Canton,

Affiliation Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autonoma de Madrid, Madrid, Spain
⨯
Isabel Sola,

Affiliation Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autonoma de Madrid, Madrid, Spain
⨯
Luis Enjuanes,

Affiliation Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autonoma de Madrid, Madrid, Spain
⨯
Peter J. Bredenbeek,

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Marjolein Kikkert,

Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Raoul J. de Groot,

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯
Frank J. M. van Kuppeveld

* E-mail: F.J.M.vanKuppeveld@uu.nl

Affiliation Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
⨯

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Huib H. Rabouw,
Martijn A. Langereis,
Robert C. M. Knaap,
Tim J. Dalebout,
Javier Canton,
Isabel Sola,
Luis Enjuanes,
Peter J. Bredenbeek,
Marjolein Kikkert,
Raoul J. de Groot

Published: October 26, 2016
https://doi.org/10.1371/journal.ppat.1005982

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