Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

• Stanislaw J. Gabryszewski,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Satish K. Dhingra,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Jill M. Combrinck,

  Affiliation Division of Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0003-0936-1761

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• Ian A. Lewis,

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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• Paul S. Callaghan,

  Affiliation Departments of Chemistry and of Biochemistry and Cellular & Molecular Biology, Georgetown University, Washington, DC, United States of America

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• Matthew R. Hassett,

  Affiliation Departments of Chemistry and of Biochemistry and Cellular & Molecular Biology, Georgetown University, Washington, DC, United States of America

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• Amila Siriwardana,

  Affiliation Departments of Chemistry and of Biochemistry and Cellular & Molecular Biology, Georgetown University, Washington, DC, United States of America

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• Philipp P. Henrich,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Andrew H. Lee,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Nina F. Gnädig,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Lise Musset,

  Affiliation Laboratoire de Parasitologie, WHO Collaborating Center for Surveillance of Anti-Malarial Drug Resistance, Institut Pasteur de la Guyane, Cayenne, French Guiana

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• Manuel Llinás,

  Affiliation Departments of Biochemistry & Molecular Biology and Chemistry, Center for Malaria Research and Center for Infectious Diseases Dynamics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Timothy J. Egan,

  Affiliation Department of Chemistry, University of Cape Town, Cape Town, South Africa

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• Paul D. Roepe,

  Affiliation Departments of Chemistry and of Biochemistry and Cellular & Molecular Biology, Georgetown University, Washington, DC, United States of America

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• David A. Fidock

  * E-mail: df2260@columbia.edu

  Affiliations Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

  http://orcid.org/0000-0001-6753-8938

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