Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Xiangyu Yao; Jian Wu; Meng Lin; Wenxiang Sun; Xiao He; Channe Gowda; Silvia Bolland; Carole A. Long; Rongfu Wang; Xin-zhuan Su

doi:10.1371/journal.ppat.1005930

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Peer-reviewed

Research Article

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Xiangyu Yao,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jian Wu,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Meng Lin,

Affiliation Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Wenxiang Sun,

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Xiao He,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Channe Gowda,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, United States of America
⨯
Silvia Bolland,

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Carole A. Long,

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Rongfu Wang ,

* E-mail: rwang3@tmhs.org (RW); xsu@niaid.nih.gov (XzS)

Affiliation Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, Texas, United States of America
⨯
Xin-zhuan Su

* E-mail: rwang3@tmhs.org (RW); xsu@niaid.nih.gov (XzS)

Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Xiangyu Yao,
Jian Wu,
Meng Lin,
Wenxiang Sun,
Xiao He,
Channe Gowda,
Silvia Bolland,
Carole A. Long,
Rongfu Wang,
Xin-zhuan Su

Published: October 7, 2016
https://doi.org/10.1371/journal.ppat.1005930

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