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Open Access
Peer-reviewed
Research Article
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death
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Naomi H. Philip,
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Alexandra DeLaney,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Lance W. Peterson,
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Melanie Santos-Marrero,
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Jennifer T. Grier,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Yan Sun,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Meghan A. Wynosky-Dolfi,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Erin E. Zwack,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Baofeng Hu,
Affiliation University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America
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Tayla M. Olsen,
Affiliation University of Washington, Department of Immunology, Seattle, Washington, United States of America
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Anthony Rongvaux,
Affiliation Fred Hutchinson Cancer Research Center, Clinical Research Division and Program in Immunology, Seattle, Washington, United States of America
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Scott D. Pope,
Affiliation Yale University School of Medicine, Department of Immunobiology, New Haven, Connecticut, United States of America
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Carolina B. López,
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Andrew Oberst,
Affiliation University of Washington, Department of Immunology, Seattle, Washington, United States of America
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Daniel P. Beiting,
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Jorge Henao-Mejia,
Affiliations University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Igor E. Brodsky
* E-mail: ibrodsky@vet.upenn.edu
Affiliations University of Pennsylvania School of Veterinary Medicine, Department of Pathobiology, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania Perelman School of Medicine, Institute for Immunology, Philadelphia, Pennsylvania, United States of America
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Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death
- Naomi H. Philip,
- Alexandra DeLaney,
- Lance W. Peterson,
- Melanie Santos-Marrero,
- Jennifer T. Grier,
- Yan Sun,
- Meghan A. Wynosky-Dolfi,
- Erin E. Zwack,
- Baofeng Hu,
- Tayla M. Olsen
![PLOS](/resource/img/logo-plos.png)
- Published: October 13, 2016
- https://doi.org/10.1371/journal.ppat.1005910