The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

• Ester Vázquez-Fernández,

  Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Matthijn R. Vos,

  Affiliation FEI Company, Nanoport Europe, Eindhoven, The Netherlands

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• Pavel Afanasyev,

  Affiliations Institute of Biology Leiden, NeCEN, Leiden, The Netherlands, The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands

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• Lino Cebey,

  Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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• Alejandro M. Sevillano,

  Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Enric Vidal,

  Affiliation IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain

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• Isaac Rosa,

  Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Ludovic Renault,

  Current address: Institute of Biology Leiden, NeCEN, Leiden, The Netherlands.

  Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

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• Adriana Ramos,

  Current address: Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

  Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Peter J. Peters,

  Affiliation The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands

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• José Jesús Fernández,

  Affiliation Centro Nacional de Biotecnologia - CSIC, Campus Universidad Autónoma, Madrid, Spain

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• Marin van Heel,

  Affiliations Institute of Biology Leiden, NeCEN, Leiden, The Netherlands, Brazilian Nanotechnology National Laboratory - LNNano, CNPEM, Campinas, São Paulo, Brazil, Faculty of Natural Science, Imperial College London, London, United Kingdom

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• Howard S. Young ,

  * E-mail: hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

  Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

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• Jesús R. Requena ,

  * E-mail: hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

  Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Holger Wille

  * E-mail: hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

  Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

  http://orcid.org/0000-0001-5102-8706

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