Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

Matthew Pace; James Williams; Ayako Kurioka; Andrew B. Gerry; Bent Jakobsen; Paul Klenerman; Nneka Nwokolo; Julie Fox; Sarah Fidler; John Frater; CHERUB Investigators

doi:10.1371/journal.ppat.1005782

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Peer-reviewed

Research Article

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

Matthew Pace,

Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Institute for Emerging Infections, The Oxford Martin School, Oxford, United Kingdom
⨯
James Williams,

Affiliation Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom
⨯
Ayako Kurioka,

Affiliation Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom
⨯
Andrew B. Gerry,

Affiliation Adaptimmune Ltd, Oxfordshire, United Kingdom
⨯
Bent Jakobsen,

Affiliation Adaptimmune Ltd, Oxfordshire, United Kingdom
⨯
Paul Klenerman,

Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Institute for Emerging Infections, The Oxford Martin School, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
⨯
Nneka Nwokolo,

Affiliation Chelsea and Westminster Hospital, London, United Kingdom
⨯
Julie Fox,

Affiliation Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' NHS Trust, London, United Kingdom
⨯
Sarah Fidler ,

Contributed equally to this work with: Sarah Fidler, John Frater

Affiliation Division of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom
⨯
John Frater ,

Contributed equally to this work with: Sarah Fidler, John Frater

* E-mail: john.frater@ndm.ox.ac.uk

Affiliations Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford, United Kingdom, Institute for Emerging Infections, The Oxford Martin School, Oxford, United Kingdom, Oxford National Institute of Health Research Biomedical Research Centre, Oxford, United Kingdom
⨯
CHERUB Investigators

¶Membership of the CHERUB Investigators is listed in the Acknowledgments.
⨯

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

Matthew Pace,
James Williams,
Ayako Kurioka,
Andrew B. Gerry,
Bent Jakobsen,
Paul Klenerman,
Nneka Nwokolo,
Julie Fox,
Sarah Fidler,
John Frater

Published: August 16, 2016
https://doi.org/10.1371/journal.ppat.1005782

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