Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Fabio Gsaller; Peter Hortschansky; Takanori Furukawa; Paul D. Carr; Bharat Rash; Javier Capilla; Christoph Müller; Franz Bracher; Paul Bowyer; Hubertus Haas; Axel A. Brakhage; Michael J. Bromley

doi:10.1371/journal.ppat.1005775

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Open Access

Peer-reviewed

Research Article

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Fabio Gsaller,

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯
Peter Hortschansky,

Affiliation Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

http://orcid.org/0000-0001-5194-9054

⨯
Takanori Furukawa,

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯
Paul D. Carr,

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯
Bharat Rash,

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯
Javier Capilla,

Affiliation Microbiology Unit, Medical School, Universitat Rovira i Virgili, Reus, Spain
⨯
Christoph Müller,

Affiliation Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University of Munich, Munich, Germany
⨯
Franz Bracher,

Affiliation Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University of Munich, Munich, Germany
⨯
Paul Bowyer,

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯
Hubertus Haas,

Affiliation Division of Molecular Biology, Biocentre, Medical University of Innsbruck, Innsbruck, Austria
⨯
Axel A. Brakhage,

Affiliations Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany, Institute for Microbiology, Friedrich Schiller University Jena, Jena, Germany
⨯
Michael J. Bromley

* E-mail: mike.bromley@manchester.ac.uk

Affiliation Manchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
⨯

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Fabio Gsaller,
Peter Hortschansky,
Takanori Furukawa,
Paul D. Carr,
Bharat Rash,
Javier Capilla,
Christoph Müller,
Franz Bracher,
Paul Bowyer,
Hubertus Haas

Published: July 20, 2016
https://doi.org/10.1371/journal.ppat.1005775

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Sterols
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Azoles
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Aspergillus fumigatus
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Biosynthesis
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