Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

Hendrik Koliwer-Brandl; Karl Syson; Robert van de Weerd; Govind Chandra; Ben Appelmelk; Marina Alber; Thomas R. Ioerger; William R. Jacobs Jr.; Jeroen Geurtsen; Stephen Bornemann; Rainer Kalscheuer

doi:10.1371/journal.ppat.1005768

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Open Access

Peer-reviewed

Research Article

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

Hendrik Koliwer-Brandl ,

Contributed equally to this work with: Hendrik Koliwer-Brandl, Karl Syson

Affiliation Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⨯
Karl Syson ,

Contributed equally to this work with: Hendrik Koliwer-Brandl, Karl Syson

Affiliation Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
⨯
Robert van de Weerd,

Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands
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Govind Chandra,

Affiliation Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom
⨯
Ben Appelmelk,

Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands
⨯
Marina Alber,

Affiliation Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⨯
Thomas R. Ioerger,

Affiliation Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, United States of America
⨯
William R. Jacobs Jr.,

Affiliation Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Jeroen Geurtsen,

Affiliation Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands
⨯
Stephen Bornemann,

Affiliation Department of Biological Chemistry, John Innes Centre, Norwich, United Kingdom
⨯
Rainer Kalscheuer

* E-mail: rainer.kalscheuer@uni-duesseldorf.de

Affiliations Institute for Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

http://orcid.org/0000-0002-3378-2067

⨯

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

Hendrik Koliwer-Brandl,
Karl Syson,
Robert van de Weerd,
Govind Chandra,
Ben Appelmelk,
Marina Alber,
Thomas R. Ioerger,
William R. Jacobs Jr.,
Jeroen Geurtsen,
Stephen Bornemann

Published: August 11, 2016
https://doi.org/10.1371/journal.ppat.1005768

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