Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

• Souad Amiar ,

  Contributed equally to this work with: Souad Amiar, James I. MacRae

  Affiliation ApicoLipid group, Institute for Advanced Biosciences UMR5309, CNRS, Université Grenoble Alpes, INSERM, Grenoble, France

  ⨯
• James I. MacRae ,

  Contributed equally to this work with: Souad Amiar, James I. MacRae

  Affiliations The Francis Crick Institute, The Ridgeway, Mill Hill, London, United Kingdom, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Damien L. Callahan,

  Affiliations Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• David Dubois,

  Affiliation ApicoLipid group, Institute for Advanced Biosciences UMR5309, CNRS, Université Grenoble Alpes, INSERM, Grenoble, France

  ⨯
• Giel G. van Dooren,

  Affiliation Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia

  ⨯
• Melanie J. Shears,

  Affiliations ApicoLipid group, Institute for Advanced Biosciences UMR5309, CNRS, Université Grenoble Alpes, INSERM, Grenoble, France, School of BioSciences, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Marie-France Cesbron-Delauw,

  Affiliation BNI group, TIMC-IMAG UMR5525 CNRS, Université Grenoble Alpes, Grenoble, France

  ⨯
• Eric Maréchal,

  Affiliation Unité de recherche (UMR) 5168, CNRS, CEA, INRA, Université Grenoble Alpes, Grenoble, France

  ⨯
• Malcolm J. McConville,

  Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Geoffrey I. McFadden ,

  ¶‡ GIM, YYB and CYB also contributed equally to this work.

  Affiliation School of BioSciences, University of Melbourne, Melbourne, Victoria, Australia

  ⨯
• Yoshiki Yamaryo-Botté ,

  * E-mail: yoshiki.yamaryo@gmail.com (YYB); cyrille.botte@ujf-grenoble.fr; cyrille.botte@gmail.com (CYB)

  ¶‡ GIM, YYB and CYB also contributed equally to this work.

  Affiliation ApicoLipid group, Institute for Advanced Biosciences UMR5309, CNRS, Université Grenoble Alpes, INSERM, Grenoble, France

  ⨯
• Cyrille Y. Botté

  * E-mail: yoshiki.yamaryo@gmail.com (YYB); cyrille.botte@ujf-grenoble.fr; cyrille.botte@gmail.com (CYB)

  ¶‡ GIM, YYB and CYB also contributed equally to this work.

  Affiliation ApicoLipid group, Institute for Advanced Biosciences UMR5309, CNRS, Université Grenoble Alpes, INSERM, Grenoble, France

  ⨯