Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding

Gopal Sapparapu; Rita Czakó; Gabriela Alvarado; Sreejesh Shanker; B. V. Venkataram Prasad; Robert L. Atmar; Mary K. Estes; James E. Crowe Jr.

doi:10.1371/journal.ppat.1005719

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Peer-reviewed

Research Article

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding

Gopal Sapparapu ,

Contributed equally to this work with: Gopal Sapparapu, Rita Czakó, Gabriela Alvarado

Affiliations Department of Pediatrics, Vanderbilt Medical Center, Nashville, Tennessee, United States of America, Vanderbilt Vaccine Center, Vanderbilt Medical Center, Nashville, Tennessee, United States of America
⨯
Rita Czakó ,

Contributed equally to this work with: Gopal Sapparapu, Rita Czakó, Gabriela Alvarado

Affiliation Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Gabriela Alvarado ,

Contributed equally to this work with: Gopal Sapparapu, Rita Czakó, Gabriela Alvarado

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt Medical Center, Nashville, Tennessee, United States of America
⨯
Sreejesh Shanker,

Affiliation Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
B. V. Venkataram Prasad,

Affiliations Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Robert L. Atmar,

Affiliations Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mary K. Estes,

Affiliations Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
James E. Crowe Jr.

* E-mail: james.crowe@vanderbilt.edu

Affiliations Department of Pediatrics, Vanderbilt Medical Center, Nashville, Tennessee, United States of America, Vanderbilt Vaccine Center, Vanderbilt Medical Center, Nashville, Tennessee, United States of America, Department of Pathology, Microbiology and Immunology, Vanderbilt Medical Center, Nashville, Tennessee, United States of America
⨯

Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding

Gopal Sapparapu,
Rita Czakó,
Gabriela Alvarado,
Sreejesh Shanker,
B. V. Venkataram Prasad,
Robert L. Atmar,
Mary K. Estes,
James E. Crowe Jr.

Published: June 29, 2016
https://doi.org/10.1371/journal.ppat.1005719

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