Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

• Paul A. Mann ,

  ¶☯ These authors contributed equally to this work.

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Anna Müller ,

  ¶☯ These authors contributed equally to this work.

  Affiliations Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany, German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany

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• Kerstin A. Wolff,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

  ⨯
• Thierry Fischmann,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Hao Wang,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Patricia Reed,

  Affiliation Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

  ⨯
• Yan Hou,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

  ⨯
• Wenjin Li,

  Affiliation PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry, University of Bonn, Bonn, Germany

  ⨯
• Christa E. Müller,

  Affiliation PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry, University of Bonn, Bonn, Germany

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• Jianying Xiao,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Nicholas Murgolo,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Xinwei Sher,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Todd Mayhood,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Payal R. Sheth,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Asra Mirza,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Marc Labroli,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

  ⨯
• Li Xiao,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Mark McCoy,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Charles J. Gill,

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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• Mariana G. Pinho,

  Affiliation Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

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• Tanja Schneider,

  Affiliations Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany, German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany

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•  [ ... ],
• Terry Roemer

  * E-mail: terry_roemer@merck.com

  Affiliation Merck Research Laboratories, Kenilworth New Jersey, United States of America

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