The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Michael P. Nicoll; William Hann; Maitreyi Shivkumar; Laura E. R. Harman; Viv Connor; Heather M. Coleman; João T. Proença; Stacey Efstathiou

doi:10.1371/journal.ppat.1005539

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Open Access

Peer-reviewed

Research Article

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Michael P. Nicoll ,

* E-mail: michael.nicoll@nibsc.org

Current address: Division of Virology, National Institute for Biological Reagents and Control, Medicines and Healthcare Products Regulatory Agency, Hertfordshire, United Kingdom

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
William Hann,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Maitreyi Shivkumar,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Laura E. R. Harman,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Viv Connor,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Heather M. Coleman,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
João T. Proença,

Current address: Instituto Gulbenkian de Ciência, Oeiras, Portugal

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
Stacey Efstathiou

Current address: Division of Virology, National Institute for Biological Reagents and Control, Medicines and Healthcare Products Regulatory Agency, Hertfordshire, United Kingdom

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Michael P. Nicoll,
William Hann,
Maitreyi Shivkumar,
Laura E. R. Harman,
Viv Connor,
Heather M. Coleman,
João T. Proença,
Stacey Efstathiou

Published: April 7, 2016
https://doi.org/10.1371/journal.ppat.1005539

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27 May 2016
15:17 GMT
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Note from the authors Posted by MPNicoll on 27 May 2016 at 15:17 GMT

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