Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye; Chen Fan; Zhiqiang Ku; Teng Zuo; Liangliang Kong; Chao Zhang; Jinping Shi; Qingwei Liu; Tan Chen; Yingyi Zhang; Wen Jiang; Linqi Zhang; Zhong Huang; Yao Cong

doi:10.1371/journal.ppat.1005454

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Open Access

Peer-reviewed

Research Article

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye ,

Contributed equally to this work with: Xiaohua Ye, Chen Fan

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Chen Fan ,

Contributed equally to this work with: Xiaohua Ye, Chen Fan

Affiliation National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Zhiqiang Ku,

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Teng Zuo,

Affiliation Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China
⨯
Liangliang Kong,

Affiliations National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai, China
⨯
Chao Zhang,

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Jinping Shi,

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Qingwei Liu,

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Tan Chen,

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Yingyi Zhang,

Affiliations National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai, China
⨯
Wen Jiang,

Affiliation Markey Center for Structural Biology, Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
⨯
Linqi Zhang,

Affiliation Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing, China
⨯
Zhong Huang ,

* E-mail: huangzhong@ips.ac.cn (ZH); cong@sibcb.ac.cn (YC)

Affiliation Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Yao Cong

* E-mail: huangzhong@ips.ac.cn (ZH); cong@sibcb.ac.cn (YC)

Affiliations National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai, China
⨯

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye,
Chen Fan,
Zhiqiang Ku,
Teng Zuo,
Liangliang Kong,
Chao Zhang,
Jinping Shi,
Qingwei Liu,
Tan Chen,
Yingyi Zhang

Published: March 3, 2016
https://doi.org/10.1371/journal.ppat.1005454

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