Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Valerie J. Klema; Mengyi Ye; Aditya Hindupur; Tadahisa Teramoto; Keerthi Gottipati; Radhakrishnan Padmanabhan; Kyung H. Choi

doi:10.1371/journal.ppat.1005451

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Peer-reviewed

Research Article

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Valerie J. Klema,

Affiliation Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Mengyi Ye,

Affiliation Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Aditya Hindupur,

Affiliation Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Tadahisa Teramoto,

Affiliation Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, D.C., United States of America
⨯
Keerthi Gottipati,

Affiliation Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Radhakrishnan Padmanabhan,

Affiliation Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, D.C., United States of America
⨯
Kyung H. Choi

* E-mail: kychoi@utmb.edu

Affiliation Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

Valerie J. Klema,
Mengyi Ye,
Aditya Hindupur,
Tadahisa Teramoto,
Keerthi Gottipati,
Radhakrishnan Padmanabhan,
Kyung H. Choi

Published: February 19, 2016
https://doi.org/10.1371/journal.ppat.1005451

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