Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase

Open Access

Peer-reviewed

Research Article

Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)^FBXW11-NSs E3 Ligase

Rajini Mudhasani,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Julie P. Tran,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Cary Retterer,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Krishna P. Kota,

Affiliations Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America, Perkin Elmer, Waltham, Massachusetts, United States of America
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Chris A. Whitehouse,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Sina Bavari

* E-mail: sina.bavari.civ@mail.mil

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Rift Valley fever virus
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Small interfering RNA
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HeLa cells
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Viral gene expression
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Ligases
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Gene expression
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Transfection
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Viral replication
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