A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

Zachary B. Davis; Andrew Cogswell; Hamish Scott; Amanda Mertsching; Julie Boucau; Daniel Wambua; Sylvie Le Gall; Vicente Planelles; Kerry S. Campbell; Edward Barker

doi:10.1371/journal.ppat.1005421

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Research Article

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

Zachary B. Davis,

Current address: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America

Affiliation Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Andrew Cogswell,

Affiliation Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Hamish Scott,

Affiliations Division of Infection and Immunity and Cell Signaling and Cell Death, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia
⨯
Amanda Mertsching,

Affiliation Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Julie Boucau,

Affiliation Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Daniel Wambua,

Affiliation Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Sylvie Le Gall,

Affiliation Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Vicente Planelles,

Affiliation Department of Pathology, University of Utah, Salt Lake City, Utah, United States of America
⨯
Kerry S. Campbell,

Affiliation Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania, United States of America
⨯
Edward Barker

* E-mail: Edward_Barker@rush.edu

Affiliation Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

Zachary B. Davis,
Andrew Cogswell,
Hamish Scott,
Amanda Mertsching,
Julie Boucau,
Daniel Wambua,
Sylvie Le Gall,
Vicente Planelles,
Kerry S. Campbell,
Edward Barker

Published: February 1, 2016
https://doi.org/10.1371/journal.ppat.1005421

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