A Higher Activation Threshold of Memory CD8⁺ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

• Stephen M. Carpenter ,

  * E-mail: steve.carpenter@umassmed.edu (SMC); samuel.behar@umassmed.edu (SMB)

  Affiliations Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

  ⨯
• Cláudio Nunes-Alves,

  Affiliations Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal, ICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, Portugal

  ⨯
• Matthew G. Booty,

  Affiliations Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Program in Immunology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Sing Sing Way,

  Affiliation Division of Infectious Diseases, Cincinnati Children’s Hospital, Cincinnati, Ohio, United States of America

  ⨯
• Samuel M. Behar

  * E-mail: steve.carpenter@umassmed.edu (SMC); samuel.behar@umassmed.edu (SMB)

  Affiliation Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

  ⨯