A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation

Eoin N. Leen; Frédéric Sorgeloos; Samantha Correia; Yasmin Chaudhry; Fabien Cannac; Chiara Pastore; Yingqi Xu; Stephen C. Graham; Stephen J. Matthews; Ian G. Goodfellow; Stephen Curry

doi:10.1371/journal.ppat.1005379

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Open Access

Peer-reviewed

Research Article

A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation

Eoin N. Leen ,

* E-mail: eoin.leen07@imperial.ac.uk (ENL); s.curry@imperial.ac.uk (SC)

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Frédéric Sorgeloos,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Samantha Correia,

Current address: Section of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Yasmin Chaudhry,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Fabien Cannac,

Current address: Department of Biology, Paul Scherrer Institut, ETH Zürich, Villigen PSI, Switzerland

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Chiara Pastore,

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Yingqi Xu,

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Stephen C. Graham,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Stephen J. Matthews,

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
Ian G. Goodfellow,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
⨯
Stephen Curry

* E-mail: eoin.leen07@imperial.ac.uk (ENL); s.curry@imperial.ac.uk (SC)

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯

A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation

Eoin N. Leen,
Frédéric Sorgeloos,
Samantha Correia,
Yasmin Chaudhry,
Fabien Cannac,
Chiara Pastore,
Yingqi Xu,
Stephen C. Graham,
Stephen J. Matthews,
Ian G. Goodfellow

Published: January 6, 2016
https://doi.org/10.1371/journal.ppat.1005379
See the preprint

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Norovirus
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Protein translation
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Translation initiation
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SDS polyacrylamide gel electrophoresis
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Calicivirus infection
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