Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Mennatallah M. Y. Albarqi; Jonathan D. Stoltzfus; Adeiye A. Pilgrim; Thomas J. Nolan; Zhu Wang; Steven A. Kliewer; David J. Mangelsdorf; James B. Lok

doi:10.1371/journal.ppat.1005358

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Peer-reviewed

Research Article

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Mennatallah M. Y. Albarqi ,

Contributed equally to this work with: Mennatallah M. Y. Albarqi, Jonathan D. Stoltzfus

Affiliations Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biology, Hollins University, Roanoke, Virginia, United States of America
⨯
Jonathan D. Stoltzfus ,

Contributed equally to this work with: Mennatallah M. Y. Albarqi, Jonathan D. Stoltzfus

Affiliations Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biology, Hollins University, Roanoke, Virginia, United States of America
⨯
Adeiye A. Pilgrim,

Affiliation Department of Biology, Hollins University, Roanoke, Virginia, United States of America
⨯
Thomas J. Nolan,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Zhu Wang,

Affiliation Department of Pharmacology, University of Texas Southwest Medical Center, Dallas, Texas, United States of America
⨯
Steven A. Kliewer,

Affiliations Department of Pharmacology, University of Texas Southwest Medical Center, Dallas, Texas, United States of America, Department of Molecular Biology, University of Texas Southwest Medical Center, Dallas, Texas, United States of America
⨯
David J. Mangelsdorf,

Affiliations Department of Pharmacology, University of Texas Southwest Medical Center, Dallas, Texas, United States of America, Howard Hughes Medical Institute, University of Texas Southwest Medical Center, Dallas, Texas, United States of America
⨯
James B. Lok

* E-mail: jlok@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Mennatallah M. Y. Albarqi,
Jonathan D. Stoltzfus,
Adeiye A. Pilgrim,
Thomas J. Nolan,
Zhu Wang,
Steven A. Kliewer,
David J. Mangelsdorf,
James B. Lok

Published: January 4, 2016
https://doi.org/10.1371/journal.ppat.1005358

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Strongyloides stercoralis
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Caenorhabditis elegans
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