TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

• Glen M. Chew,

  Affiliation Hawaii Center for HIV/AIDS, Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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• Tsuyoshi Fujita,

  Affiliations Hawaii Center for HIV/AIDS, Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America, Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan

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• Gabriela M. Webb,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Benjamin J. Burwitz,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Helen L. Wu,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Jason S. Reed,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Katherine B. Hammond,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Kiera L. Clayton,

  Affiliation Department of Immunology, University of Toronto, Toronto, Ontario, Canada

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• Naoto Ishii,

  Affiliation Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan

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• Mohamed Abdel-Mohsen,

  Affiliation Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America

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• Teri Liegler,

  Affiliation Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America

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• Brooks I. Mitchell,

  Affiliation Hawaii Center for HIV/AIDS, Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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• Frederick M. Hecht,

  Affiliation HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America

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• Mario Ostrowski,

  Affiliation Department of Immunology, University of Toronto, Toronto, Ontario, Canada

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• Cecilia M. Shikuma,

  Affiliation Hawaii Center for HIV/AIDS, Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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• Scott G. Hansen,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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• Mark Maurer,

  Affiliation Biologics Discovery California, Bristol-Myers Squibb, Redwood City, California, United States of America

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• Alan J. Korman,

  Affiliation Biologics Discovery California, Bristol-Myers Squibb, Redwood City, California, United States of America

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• Steven G. Deeks,

  Affiliation HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, United States of America

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• Jonah B. Sacha ,

  ¶‡ JBS and LCN share equal co-senior authorship.

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

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•  [ ... ],
• Lishomwa C. Ndhlovu

  * E-mail: lndhlovu@hawaii.edu

  ¶‡ JBS and LCN share equal co-senior authorship.

  Affiliation Hawaii Center for HIV/AIDS, Department of Tropical Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America

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