Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

• Bianca Schmid ,

  Contributed equally to this work with: Bianca Schmid, Melanie Rinas

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Melanie Rinas ,

  Contributed equally to this work with: Bianca Schmid, Melanie Rinas

  Affiliations Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany, BioQuant Center, University of Heidelberg, Heidelberg, Germany

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• Alessia Ruggieri,

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Eliana Gisela Acosta,

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Marie Bartenschlager,

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Antje Reuter,

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Wolfgang Fischl,

  Current address: Haplogen GmbH, Vienna, Austria

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Nathalie Harder,

  Affiliations BioQuant Center, University of Heidelberg, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

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• Jan-Philip Bergeest,

  Affiliations BioQuant Center, University of Heidelberg, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

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• Michael Flossdorf,

  Affiliations Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany, BioQuant Center, University of Heidelberg, Heidelberg, Germany

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• Karl Rohr,

  Affiliations BioQuant Center, University of Heidelberg, Heidelberg, Germany, Department of Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

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• Thomas Höfer ,

  * E-mail: t.hoefer@dkfz-heidelberg.de (TH); Ralf_Bartenschlager@med.uni-heidelberg.de (RB)

  Affiliations Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany, BioQuant Center, University of Heidelberg, Heidelberg, Germany

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• Ralf Bartenschlager

  * E-mail: t.hoefer@dkfz-heidelberg.de (TH); Ralf_Bartenschlager@med.uni-heidelberg.de (RB)

  Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

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