Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Norberto González-Juarbe; Ryan Paul Gilley; Cecilia Anahí Hinojosa; Kelley Margaret Bradley; Akinobu Kamei; Geli Gao; Peter Herman Dube; Molly Ann Bergman; Carlos Javier Orihuela

doi:10.1371/journal.ppat.1005337

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Open Access

Peer-reviewed

Research Article

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Norberto González-Juarbe,

Affiliations Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Ryan Paul Gilley,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Cecilia Anahí Hinojosa,

Affiliations Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Kelley Margaret Bradley,

Affiliation Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Akinobu Kamei,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Geli Gao,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Peter Herman Dube,

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Molly Ann Bergman ,

Current address: Belmont, Massachusetts, United States of America

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Carlos Javier Orihuela

* E-mail: corihuel@uab.edu

¶‡ These authors are joint senior authors on this work.

Affiliations Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

Norberto González-Juarbe,
Ryan Paul Gilley,
Cecilia Anahí Hinojosa,
Kelley Margaret Bradley,
Akinobu Kamei,
Geli Gao,
Peter Herman Dube,
Molly Ann Bergman,
Carlos Javier Orihuela

Published: December 11, 2015
https://doi.org/10.1371/journal.ppat.1005337

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Macrophages
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Serratia marcescens
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Necrotic cell death
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Alveolar macrophages
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Pneumococcus
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Staphylococcus aureus
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