Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

Devender Kumar; Laura C. Ristow; Meiqing Shi; Priyanka Mukherjee; Jennifer A. Caine; Woo-Yong Lee; Paul Kubes; Jenifer Coburn; George Chaconas

doi:10.1371/journal.ppat.1005333

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Peer-reviewed

Research Article

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

Devender Kumar,

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
Laura C. Ristow,

Current address: Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America

Affiliations Graduate Program in Microbiology, Immunology, and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Meiqing Shi,

Current address: Department of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Priyanka Mukherjee,

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
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Jennifer A. Caine,

Affiliations Graduate Program in Microbiology, Immunology, and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Woo-Yong Lee,

Affiliations Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Paul Kubes,

Affiliations Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Jenifer Coburn,

Affiliations Graduate Program in Microbiology, Immunology, and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, Unites States of America
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George Chaconas

* E-mail: Chaconas@ucalgary.ca

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

Devender Kumar,
Laura C. Ristow,
Meiqing Shi,
Priyanka Mukherjee,
Jennifer A. Caine,
Woo-Yong Lee,
Paul Kubes,
Jenifer Coburn,
George Chaconas

Published: December 18, 2015
https://doi.org/10.1371/journal.ppat.1005333

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Spirochetes
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Borrelia burgdorferi
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