Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

• Alain Le Coupanec ,

  Contributed equally to this work with: Alain Le Coupanec, Marc Desforges

  Affiliation Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada

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• Marc Desforges ,

  Contributed equally to this work with: Alain Le Coupanec, Marc Desforges

  * E-mail: marc.desforges@iaf.inrs.ca (MDe); pierre.talbot@iaf.inrs.ca (PJT)

  Affiliation Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada

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• Mathieu Meessen-Pinard,

  Affiliation Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada

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• Mathieu Dubé,

  Affiliation Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada

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• Robert Day,

  Affiliation Institut de Pharmacologie de Sherbrooke, Faculté de Médecine et Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada

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• Nabil G. Seidah,

  Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montréal, Québec, Canada

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• Pierre J. Talbot

  * E-mail: marc.desforges@iaf.inrs.ca (MDe); pierre.talbot@iaf.inrs.ca (PJT)

  Affiliation Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada

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