Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

Ziying Han; Jonathan J. Madara; Andrew Herbert; Laura I. Prugar; Gordon Ruthel; Jianhong Lu; Yuliang Liu; Wenbo Liu; Xiaohong Liu; Jay E. Wrobel; Allen B. Reitz; John M. Dye; Ronald N. Harty; Bruce D. Freedman

doi:10.1371/journal.ppat.1005220

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Open Access

Peer-reviewed

Research Article

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

Ziying Han,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jonathan J. Madara,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Andrew Herbert,

Affiliation United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
⨯
Laura I. Prugar,

Affiliation United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
⨯
Gordon Ruthel,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jianhong Lu,

Current address: Cancer Research Institute, Central South University, Changsha, Hunan, People's Republic of China

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Yuliang Liu,

Current address: Poultry Disease Laboratory, National Veterinary Diagnostic Center (NVDC), China Animal Disease Control Center (CADC), Beijing, China

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Wenbo Liu,

Current address: Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Xiaohong Liu,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jay E. Wrobel,

Affiliation Fox Chase Chemical Diversity Center, Inc., Doylestown, Pennsylvania, United States of America
⨯
Allen B. Reitz,

Affiliation Fox Chase Chemical Diversity Center, Inc., Doylestown, Pennsylvania, United States of America
⨯
John M. Dye,

Affiliation United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
⨯
Ronald N. Harty ,

* E-mail: rharty@vet.upenn.edu (RNH); bruce@vet.upenn.edu (BDF)

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Bruce D. Freedman

* E-mail: rharty@vet.upenn.edu (RNH); bruce@vet.upenn.edu (BDF)

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention

Ziying Han,
Jonathan J. Madara,
Andrew Herbert,
Laura I. Prugar,
Gordon Ruthel,
Jianhong Lu,
Yuliang Liu,
Wenbo Liu,
Xiaohong Liu,
Jay E. Wrobel

Published: October 29, 2015
https://doi.org/10.1371/journal.ppat.1005220

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