Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Jose M. Jimenez-Guardeño; Jose A. Regla-Nava; Jose L. Nieto-Torres; Marta L. DeDiego; Carlos Castaño-Rodriguez; Raul Fernandez-Delgado; Stanley Perlman; Luis Enjuanes

doi:10.1371/journal.ppat.1005215

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Open Access

Peer-reviewed

Research Article

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Jose M. Jimenez-Guardeño ,

Contributed equally to this work with: Jose M. Jimenez-Guardeño, Jose A. Regla-Nava

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Jose A. Regla-Nava ,

Contributed equally to this work with: Jose M. Jimenez-Guardeño, Jose A. Regla-Nava

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Jose L. Nieto-Torres,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Marta L. DeDiego,

Current address: David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Carlos Castaño-Rodriguez,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Raul Fernandez-Delgado,

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯
Stanley Perlman,

Affiliation Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Luis Enjuanes

* E-mail: L.Enjuanes@cnb.csic.es

Affiliation Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain
⨯

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

Jose M. Jimenez-Guardeño,
Jose A. Regla-Nava,
Jose L. Nieto-Torres,
Marta L. DeDiego,
Carlos Castaño-Rodriguez,
Raul Fernandez-Delgado,
Stanley Perlman,
Luis Enjuanes

Published: October 29, 2015
https://doi.org/10.1371/journal.ppat.1005215

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