Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Fikadu G. Tafesse; Ali Rashidfarrokhi; Florian I. Schmidt; Elizaveta Freinkman; Stephanie Dougan; Michael Dougan; Alexandre Esteban; Takeshi Maruyama; Karin Strijbis; Hidde L. Ploegh

doi:10.1371/journal.ppat.1005188

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Open Access

Peer-reviewed

Research Article

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Fikadu G. Tafesse ,

Contributed equally to this work with: Fikadu G. Tafesse, Ali Rashidfarrokhi

* E-mail: tafesse@wi.mit.edu, ftafesse@mgh.harvard.edu

Affiliations Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Ali Rashidfarrokhi ,

Contributed equally to this work with: Fikadu G. Tafesse, Ali Rashidfarrokhi

Affiliations Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Florian I. Schmidt,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Elizaveta Freinkman,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Stephanie Dougan,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Michael Dougan,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Alexandre Esteban,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Takeshi Maruyama,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Karin Strijbis,

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Hidde L. Ploegh

Affiliation Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Fikadu G. Tafesse,
Ali Rashidfarrokhi,
Florian I. Schmidt,
Elizaveta Freinkman,
Stephanie Dougan,
Michael Dougan,
Alexandre Esteban,
Takeshi Maruyama,
Karin Strijbis,
Hidde L. Ploegh

Published: October 2, 2015
https://doi.org/10.1371/journal.ppat.1005188

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Sphingolipids
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Candida albicans
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Lipids
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