The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Yorihiro Nishimura; Noel P. McLaughlin; Jieyan Pan; Sara Goldstein; Susan Hafenstein; Hiroyuki Shimizu; Jeffrey D. Winkler; Jeffrey M. Bergelson

doi:10.1371/journal.ppat.1005184

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Research Article

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Yorihiro Nishimura ,

* E-mail: ynishi@nih.go.jp (YN); winkler@sas.upenn.edu (JDW); bergelson@email.chop.edu (JMB)

Affiliations Division of Infectious Diseases, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Virology II, National Institute of Infectious Diseases, Musashimurayama-shi, Tokyo, Japan
⨯
Noel P. McLaughlin,

Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jieyan Pan,

Affiliation Division of Infectious Diseases, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Sara Goldstein,

Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Susan Hafenstein,

Affiliation Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
⨯
Hiroyuki Shimizu,

Affiliation Department of Virology II, National Institute of Infectious Diseases, Musashimurayama-shi, Tokyo, Japan
⨯
Jeffrey D. Winkler ,

* E-mail: ynishi@nih.go.jp (YN); winkler@sas.upenn.edu (JDW); bergelson@email.chop.edu (JMB)

Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jeffrey M. Bergelson

* E-mail: ynishi@nih.go.jp (YN); winkler@sas.upenn.edu (JDW); bergelson@email.chop.edu (JMB)

Affiliations Division of Infectious Diseases, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Yorihiro Nishimura,
Noel P. McLaughlin,
Jieyan Pan,
Sara Goldstein,
Susan Hafenstein,
Hiroyuki Shimizu,
Jeffrey D. Winkler,
Jeffrey M. Bergelson

Published: October 2, 2015
https://doi.org/10.1371/journal.ppat.1005184

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