DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation

Open Access

Peer-reviewed

Research Article

Tai An,

Affiliations The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China, The College of Basic Medical Science, Shaanxi University of Chinese Medicine, Xi’an, China
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Shu Li,

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Wei Pan,

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Po Tien,

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Bo Zhong,

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Hong-Bing Shu,

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Shuwen Wu

* E-mail: shuwenwu@hotmail.com

Affiliation The College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China
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Transfection
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HEK 293 cells
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Phosphorylation
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Immunoprecipitation
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Ubiquitination
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Interferons
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Transcription factors
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RNA interference
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