Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

Luigi De Colibus; Xiangxi Wang; Aloys Tijsma; Johan Neyts; John A. B. Spyrou; Jingshan Ren; Jonathan M. Grimes; Gerhard Puerstinger; Pieter Leyssen; Elizabeth E. Fry; Zihe Rao; David I. Stuart

doi:10.1371/journal.ppat.1005165

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Peer-reviewed

Research Article

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

Luigi De Colibus ,

Contributed equally to this work with: Luigi De Colibus, Xiangxi Wang

Affiliation Division of Structural Biology, University of Oxford, Oxford, United Kingdom
⨯
Xiangxi Wang ,

Contributed equally to this work with: Luigi De Colibus, Xiangxi Wang

Affiliation National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China
⨯
Aloys Tijsma,

Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Johan Neyts,

Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
John A. B. Spyrou,

Affiliation Division of Structural Biology, University of Oxford, Oxford, United Kingdom
⨯
Jingshan Ren,

Affiliation Division of Structural Biology, University of Oxford, Oxford, United Kingdom
⨯
Jonathan M. Grimes,

Affiliations Division of Structural Biology, University of Oxford, Oxford, United Kingdom, Diamond Light Source, Didcot, United Kingdom
⨯
Gerhard Puerstinger,

Affiliation Department of Pharmaceutical Chemistry, University of Innsbruck, Innsbruck, Austria
⨯
Pieter Leyssen,

Affiliation Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Elizabeth E. Fry,

Affiliation Division of Structural Biology, University of Oxford, Oxford, United Kingdom
⨯
Zihe Rao ,

* E-mail: raozh@xtal.tsinghua.edu.cn (ZR); dave@strubi.ox.ac.uk (DIS)

Affiliations National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China, Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China
⨯
David I. Stuart

* E-mail: raozh@xtal.tsinghua.edu.cn (ZR); dave@strubi.ox.ac.uk (DIS)

Affiliations Division of Structural Biology, University of Oxford, Oxford, United Kingdom, Diamond Light Source, Didcot, United Kingdom
⨯

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

Luigi De Colibus,
Xiangxi Wang,
Aloys Tijsma,
Johan Neyts,
John A. B. Spyrou,
Jingshan Ren,
Jonathan M. Grimes,
Gerhard Puerstinger,
Pieter Leyssen,
Elizabeth E. Fry

Published: October 20, 2015
https://doi.org/10.1371/journal.ppat.1005165

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