Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

Yan Sun; Deepika Jain; Cynthia J. Koziol-White; Emmanuelle Genoyer; Micah Gilbert; Karla Tapia; Reynold A. Panettieri Jr.; Richard L. Hodinka; Carolina B. López

doi:10.1371/journal.ppat.1005122

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Peer-reviewed

Research Article

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

Yan Sun,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Deepika Jain,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Cynthia J. Koziol-White,

Affiliation Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Emmanuelle Genoyer,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Micah Gilbert,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Karla Tapia,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Reynold A. Panettieri Jr.,

Affiliation Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Richard L. Hodinka,

Current address: Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, Greenville, South Carolina, United States of America

Affiliation Department of Pathology and Laboratory of Medicine, Perelman School of Medicine at the University of Pennsylvania and Clinical Virology Laboratory, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Carolina B. López

* E-mail: lopezca@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

Yan Sun,
Deepika Jain,
Cynthia J. Koziol-White,
Emmanuelle Genoyer,
Micah Gilbert,
Karla Tapia,
Reynold A. Panettieri Jr.,
Richard L. Hodinka,
Carolina B. López

Published: September 3, 2015
https://doi.org/10.1371/journal.ppat.1005122

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