HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Yik-Khuan Ho; Huijun Zhi; Tara Bowlin; Batsukh Dorjbal; Subha Philip; Muhammad Atif Zahoor; Hsiu-Ming Shih; Oliver John Semmes; Brian Schaefer; J. N. Mark Glover; Chou-Zen Giam

doi:10.1371/journal.ppat.1005102

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Open Access

Peer-reviewed

Research Article

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Yik-Khuan Ho,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Huijun Zhi,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Tara Bowlin,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Batsukh Dorjbal,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Subha Philip,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Muhammad Atif Zahoor,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Hsiu-Ming Shih,

Affiliation Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
⨯
Oliver John Semmes,

Affiliation Department of Microbiology and Molecular Cell Biology, The Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Brian Schaefer,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
J. N. Mark Glover,

Affiliation Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
⨯
Chou-Zen Giam

* E-mail: chou-zen.giam@usuhs.edu

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Yik-Khuan Ho,
Huijun Zhi,
Tara Bowlin,
Batsukh Dorjbal,
Subha Philip,
Muhammad Atif Zahoor,
Hsiu-Ming Shih,
Oliver John Semmes,
Brian Schaefer,
J. N. Mark Glover

Published: August 18, 2015
https://doi.org/10.1371/journal.ppat.1005102

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