STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Karoly Toth; Sang R. Lee; Baoling Ying; Jacqueline F. Spencer; Ann E. Tollefson; John E. Sagartz; Il-Keun Kong; Zhongde Wang; William S. M. Wold

doi:10.1371/journal.ppat.1005084

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Research Article

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Karoly Toth ,

Contributed equally to this work with: Karoly Toth, Sang R. Lee, Baoling Ying

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Sang R. Lee ,

Contributed equally to this work with: Karoly Toth, Sang R. Lee, Baoling Ying

Affiliation Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
⨯
Baoling Ying ,

Contributed equally to this work with: Karoly Toth, Sang R. Lee, Baoling Ying

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jacqueline F. Spencer,

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Ann E. Tollefson,

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
John E. Sagartz,

Affiliation Department of Comparative Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯
Il-Keun Kong,

Affiliation Department of Animal Science, Division of Applied Life Science and Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Republic of Korea
⨯
Zhongde Wang ,

* E-mail: zonda.wang@usu.edu (ZW); woldws@slu.edu (WSMW)

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
⨯
William S. M. Wold

* E-mail: zonda.wang@usu.edu (ZW); woldws@slu.edu (WSMW)

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
⨯

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Karoly Toth,
Sang R. Lee,
Baoling Ying,
Jacqueline F. Spencer,
Ann E. Tollefson,
John E. Sagartz,
Il-Keun Kong,
Zhongde Wang,
William S. M. Wold

Published: August 20, 2015
https://doi.org/10.1371/journal.ppat.1005084

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