IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ

Gongguan Liu; Jinjun Xu; Hui Wu; Donglei Sun; Xiquan Zhang; Xiaoping Zhu; Stefan Magez; Meiqing Shi

doi:10.1371/journal.ppat.1005065

Loading metrics

Open Access

Peer-reviewed

Research Article

IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4⁺ T Cells and IFN-γ

Gongguan Liu,

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Jinjun Xu,

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Hui Wu,

Current address: Department of Obstetrics and Gynecology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Donglei Sun,

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Xiquan Zhang,

Affiliation Department of Animal Genetics, Breeding and Reproduction, South China Agricultural University, Guangzhou, China
⨯
Xiaoping Zhu,

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Stefan Magez,

Affiliations Laboratory for Cellular and Molecular Immunology, Vrije Universiteit Brussels, Brussels, Belgium, Structural Biology Research Centre, VIB, Brussels, Belgium
⨯
Meiqing Shi

* E-mail: mshi@umd.edu

Affiliation Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯

IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4⁺ T Cells and IFN-γ

Gongguan Liu,
Jinjun Xu,
Hui Wu,
Donglei Sun,
Xiquan Zhang,
Xiaoping Zhu,
Stefan Magez,
Meiqing Shi

Published: July 29, 2015
https://doi.org/10.1371/journal.ppat.1005065

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Trypanosoma
Is the Subject Area "Trypanosoma" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Protozoan infections
Is the Subject Area "Protozoan infections" applicable to this article?

Thanks for your feedback.
Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.