An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction

Arlet Minassian; Junjie Zhang; Shanping He; Jun Zhao; Ebrahim Zandi; Takeshi Saito; Chengyu Liang; Pinghui Feng

doi:10.1371/journal.ppat.1005060

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Peer-reviewed

Research Article

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction

Arlet Minassian ,

Contributed equally to this work with: Arlet Minassian, Junjie Zhang

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Junjie Zhang ,

Contributed equally to this work with: Arlet Minassian, Junjie Zhang

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Shanping He,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Jun Zhao,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Ebrahim Zandi,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Takeshi Saito,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Chengyu Liang,

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
Pinghui Feng

* E-mail: pinghui.feng@usc.edu

Affiliation Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction

Arlet Minassian,
Junjie Zhang,
Shanping He,
Jun Zhao,
Ebrahim Zandi,
Takeshi Saito,
Chengyu Liang,
Pinghui Feng

Published: July 29, 2015
https://doi.org/10.1371/journal.ppat.1005060

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