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Open Access
Peer-reviewed
Research Article
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
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Sampa Santra ,
Contributed equally to this work with: Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely
* E-mail: ssantra@bidmc.harvard.edu (SS); gdt@duke.edu (GDT); hayne002@mc.duke.edu (BFH)
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
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Georgia D. Tomaras ,
Contributed equally to this work with: Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely
* E-mail: ssantra@bidmc.harvard.edu (SS); gdt@duke.edu (GDT); hayne002@mc.duke.edu (BFH)
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Ranjit Warrier ,
Contributed equally to this work with: Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely
Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Nathan I. Nicely ,
Contributed equally to this work with: Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Hua-Xin Liao,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Justin Pollara,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Pinghuang Liu,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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S. Munir Alam,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Ruijun Zhang,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Sarah L. Cocklin,
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
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Xiaoying Shen,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Ryan Duffy,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Shi-Mao Xia,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Robert J. Schutte,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Charles W. Pemble IV,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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S. Moses Dennison,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Hui Li,
Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Andrew Chao,
Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Kora Vidnovic,
Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Abbey Evans,
Affiliation Department of Medicine, St Mary’s Campus, Imperial College London, London, United Kingdom
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Katja Klein,
Affiliation Department of Medicine, St Mary’s Campus, Imperial College London, London, United Kingdom
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Amit Kumar,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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James Robinson,
Affiliation Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
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Gary Landucci,
Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Irvine, Irvine, California, United States of America
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Donald N. Forthal,
Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Irvine, Irvine, California, United States of America
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David C. Montefiori,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Jaranit Kaewkungwal,
Affiliation Tropical Hygiene, Mahidol University, Bangkok, Thailand
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Sorachai Nitayaphan,
Affiliation Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand
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Punnee Pitisuttithum,
Affiliation Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand
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Supachai Rerks-Ngarm,
Affiliation Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
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Merlin L. Robb,
Affiliation US Military Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
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Nelson L. Michael,
Affiliation US Military Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
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Jerome H. Kim,
Current address: Gwanak-ro, Gwanak-gu, Seoul, Korea
Affiliation US Military Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
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Kelly A. Soderberg,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Elena E. Giorgi,
Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
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Lily Blair,
Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
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Bette T. Korber,
Affiliation Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
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Christiane Moog,
Affiliation U1109, INSERM University of Strasbourg, Strasbourg, Alsace, France
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Robin J. Shattock,
Affiliation Department of Medicine, St Mary’s Campus, Imperial College London, London, United Kingdom
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Norman L. Letvin †,
† Deceased.
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
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Joern E. Schmitz,
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
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M. A. Moody,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Feng Gao,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Guido Ferrari,
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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George M. Shaw,
Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Barton F. Haynes
* E-mail: ssantra@bidmc.harvard.edu (SS); gdt@duke.edu (GDT); hayne002@mc.duke.edu (BFH)
Affiliation Duke Human Vaccine Institute, Duke School of Medicine, Durham, North Carolina, United States of America
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Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
- Sampa Santra,
- Georgia D. Tomaras,
- Ranjit Warrier,
- Nathan I. Nicely,
- Hua-Xin Liao,
- Justin Pollara,
- Pinghuang Liu,
- S. Munir Alam,
- Ruijun Zhang,
- Sarah L. Cocklin
- Published: August 3, 2015
- https://doi.org/10.1371/journal.ppat.1005042