BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta; Sujoy Dutta; Mohanan Valiya Veettil; Arunava Roy; Mairaj Ahmed Ansari; Jawed Iqbal; Leela Chikoti; Binod Kumar; Karen E. Johnson; Bala Chandran

doi:10.1371/journal.ppat.1005030

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Peer-reviewed

Research Article

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta ,

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Sujoy Dutta ,

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Mohanan Valiya Veettil,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Arunava Roy,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Mairaj Ahmed Ansari,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Jawed Iqbal,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Leela Chikoti,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Binod Kumar,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Karen E. Johnson,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Bala Chandran

* E-mail: bala.chandran@rosalindfranklin.edu

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta,
Sujoy Dutta,
Mohanan Valiya Veettil,
Arunava Roy,
Mairaj Ahmed Ansari,
Jawed Iqbal,
Leela Chikoti,
Binod Kumar,
Karen E. Johnson,
Bala Chandran

Published: June 29, 2015
https://doi.org/10.1371/journal.ppat.1005030

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