Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Justin M. Richner; Grzegorz B. Gmyrek; Jennifer Govero; Yizheng Tu; Gerritje J. W. van der Windt; Talibah U. Metcalf; Elias K. Haddad; Johannes Textor; Mark J. Miller; Michael S. Diamond

doi:10.1371/journal.ppat.1005027

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Peer-reviewed

Research Article

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Justin M. Richner,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Grzegorz B. Gmyrek,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jennifer Govero,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yizheng Tu,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Gerritje J. W. van der Windt,

Affiliation Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Talibah U. Metcalf,

Affiliation Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America
⨯
Elias K. Haddad,

Affiliation Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America
⨯
Johannes Textor,

Affiliation Department of Theoretical Biology & Bioinformatics, Utrecht University, Utrecht, Netherlands
⨯
Mark J. Miller,

Affiliation Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Michael S. Diamond

* E-mail: diamond@borcim.wustl.edu

Affiliations Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Justin M. Richner,
Grzegorz B. Gmyrek,
Jennifer Govero,
Yizheng Tu,
Gerritje J. W. van der Windt,
Talibah U. Metcalf,
Elias K. Haddad,
Johannes Textor,
Mark J. Miller,
Michael S. Diamond

Published: July 23, 2015
https://doi.org/10.1371/journal.ppat.1005027

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24 Jul 2015
09:27 GMT
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