Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

Joy Ogbechi; Marie-Thérèse Ruf; Belinda S. Hall; Katherine Bodman-Smith; Moritz Vogel; Hua-Lin Wu; Alexander Stainer; Charles T. Esmon; Josefin Ahnström; Gerd Pluschke; Rachel E. Simmonds

doi:10.1371/journal.ppat.1005011

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Open Access

Peer-reviewed

Research Article

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

Joy Ogbechi,

Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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Marie-Thérèse Ruf,

Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Belinda S. Hall,

Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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Katherine Bodman-Smith,

Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
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Moritz Vogel,

Affiliation Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany
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Hua-Lin Wu,

Affiliation Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan
⨯
Alexander Stainer,

Affiliation Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom
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Charles T. Esmon,

Affiliation Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
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Josefin Ahnström,

Affiliation Centre for Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom
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Gerd Pluschke,

Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Rachel E. Simmonds

* E-mail: rachel.simmonds@surrey.ac.uk

Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
⨯

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

Joy Ogbechi,
Marie-Thérèse Ruf,
Belinda S. Hall,
Katherine Bodman-Smith,
Moritz Vogel,
Hua-Lin Wu,
Alexander Stainer,
Charles T. Esmon,
Josefin Ahnström,
Gerd Pluschke

Published: July 16, 2015
https://doi.org/10.1371/journal.ppat.1005011

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Fibrin
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Endothelial cells
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Buruli ulcer
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Lesions
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Necrosis
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Biopsy
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Scanning confocal microscopy
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Thrombin
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