IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

Stephanie M. Coomes; Victoria S. Pelly; Yashaswini Kannan; Isobel S. Okoye; Stephanie Czieso; Lewis J. Entwistle; Jimena Perez-Lloret; Nikolay Nikolov; Alexandre J. Potocnik; Judit Biró; Jean Langhorne; Mark S. Wilson

doi:10.1371/journal.ppat.1004994

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Open Access

Peer-reviewed

Research Article

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

Stephanie M. Coomes,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Victoria S. Pelly,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Yashaswini Kannan,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Isobel S. Okoye,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Stephanie Czieso,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Lewis J. Entwistle,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Jimena Perez-Lloret,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Nikolay Nikolov,

Affiliation Division of Systems Biology, The Francis Crick Institute, London, United Kingdom
⨯
Alexandre J. Potocnik,

Current Address: Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Judit Biró,

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯
Jean Langhorne,

Affiliation Division of Parasitology, Mill Hill Laboratories, London, United Kingdom
⨯
Mark S. Wilson

* E-mail: mark.wilson@crick.ac.uk

Affiliation Division of Molecular Immunology, The Francis Crick Institute, London, United Kingdom
⨯

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

Stephanie M. Coomes,
Victoria S. Pelly,
Yashaswini Kannan,
Isobel S. Okoye,
Stephanie Czieso,
Lewis J. Entwistle,
Jimena Perez-Lloret,
Nikolay Nikolov,
Alexandre J. Potocnik,
Judit Biró

Published: July 6, 2015
https://doi.org/10.1371/journal.ppat.1004994

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T helper cells
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Plasmodium
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Helminth infections
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