Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

• Jason H. Melehani ,

  Contributed equally to this work with: Jason H. Melehani, David B. A. James

  Affiliation Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• David B. A. James ,

  Contributed equally to this work with: Jason H. Melehani, David B. A. James

  Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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• Ashley L. DuMont,

  Current address: Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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• Victor J. Torres ,

  * E-mail: Victor.Torres@nyumc.org (VJT); jaduncan@med.unc.edu (JAD)

  Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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• Joseph A. Duncan

  * E-mail: Victor.Torres@nyumc.org (VJT); jaduncan@med.unc.edu (JAD)

  Affiliations Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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