NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

Jennifer Cnops; Carl De Trez; Benoit Stijlemans; Jiri Keirsse; Florence Kauffmann; Mark Barkhuizen; Roanne Keeton; Louis Boon; Frank Brombacher; Stefan Magez

doi:10.1371/journal.ppat.1004964

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Research Article

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

Jennifer Cnops,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium
⨯
Carl De Trez,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium
⨯
Benoit Stijlemans,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Myeloid Cell Immunology, VIB, Brussels, Belgium
⨯
Jiri Keirsse,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Myeloid Cell Immunology, VIB, Brussels, Belgium
⨯
Florence Kauffmann,

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium
⨯
Mark Barkhuizen,

Affiliations International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa, Faculty of Health Sciences (IDM, Division Immunology), University of Cape Town, Cape Town, South Africa
⨯
Roanne Keeton,

Affiliation Faculty of Health Sciences (IDM, Division Immunology), University of Cape Town, Cape Town, South Africa
⨯
Louis Boon,

Affiliation Bioceros, Utrecht, The Netherlands
⨯
Frank Brombacher,

Affiliations International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa, Faculty of Health Sciences (IDM, Division Immunology), University of Cape Town, Cape Town, South Africa
⨯
Stefan Magez

* E-mail: stemagez@vub.ac.be (SM); frank.brombacher@icgeb.org (FB)

Affiliations Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Faculty of Health Sciences (IDM, Division Immunology), University of Cape Town, Cape Town, South Africa
⨯

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

Jennifer Cnops,
Carl De Trez,
Benoit Stijlemans,
Jiri Keirsse,
Florence Kauffmann,
Mark Barkhuizen,
Roanne Keeton,
Louis Boon,
Frank Brombacher,
Stefan Magez

Published: June 12, 2015
https://doi.org/10.1371/journal.ppat.1004964

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