Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

Open Access

Peer-reviewed

Research Article

Shrenik C. Mehta,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Kacie Rice,

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Timothy Palzkill

* E-mail: timothyp@bcm.edu

Affiliation Department of Pharmacology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

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Hydrolysis
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Antibiotic resistance
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Antibiotics
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Enzymes
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Substitution mutation
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Thermal stability
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Penicillin
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Enzyme kinetics
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