The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation

• Anders Friberg ,

  Contributed equally to this work with: Anders Friberg, Sybille Thumann

  Current address: Bayer Pharma AG, Global Drug Discovery—Lead Discovery Berlin, Berlin, Germany

  Affiliations Institute of Structural Biology, Helmholtz Zentrum München, National Research Center for Environmental Health, Neuherberg, Germany, Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany

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• Sybille Thumann ,

  Contributed equally to this work with: Anders Friberg, Sybille Thumann

  Affiliation Department of Gene Vectors, Hematologikum, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

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• Janosch Hennig,

  Affiliations Institute of Structural Biology, Helmholtz Zentrum München, National Research Center for Environmental Health, Neuherberg, Germany, Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany

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• Peijian Zou,

  Affiliations Institute of Structural Biology, Helmholtz Zentrum München, National Research Center for Environmental Health, Neuherberg, Germany, Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany, Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

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• Elfriede Nössner,

  Affiliation Institute of Molecular Immunology, Hematologikum, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

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• Paul D. Ling,

  Affiliation Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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• Michael Sattler ,

  * E-mail: sattler@helmholtz-muenchen.de (MS); kempkes@helmholtz-muenchen.de (BK)

  Affiliations Institute of Structural Biology, Helmholtz Zentrum München, National Research Center for Environmental Health, Neuherberg, Germany, Center for Integrated Protein Science Munich at Chair Biomolecular NMR Spectroscopy, Department Chemie, Technische Universität München, Garching, Germany, Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

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• Bettina Kempkes

  * E-mail: sattler@helmholtz-muenchen.de (MS); kempkes@helmholtz-muenchen.de (BK)

  Affiliation Department of Gene Vectors, Hematologikum, Helmholtz Zentrum München, National Research Center for Environmental Health, München, Germany

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