Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

Éric Bergeron; Marko Zivcec; Ayan K. Chakrabarti; Stuart T. Nichol; César G. Albariño; Christina F. Spiropoulou

doi:10.1371/journal.ppat.1004879

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Research Article

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

Éric Bergeron ,

* E-mail: ebergeron@cdc.gov

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
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Marko Zivcec,

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Ayan K. Chakrabarti,

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
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Stuart T. Nichol,

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
César G. Albariño,

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
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Christina F. Spiropoulou

Affiliation Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin

Éric Bergeron,
Marko Zivcec,
Ayan K. Chakrabarti,
Stuart T. Nichol,
César G. Albariño,
Christina F. Spiropoulou

Published: May 1, 2015
https://doi.org/10.1371/journal.ppat.1004879

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Transfection
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Glycoproteins
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Virus glycoproteins
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Crimean-Congo hemorrhagic fever
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Viral replication
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Reverse genetics
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Virions
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Ribonucleoproteins
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