Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages

Yannick Morias; Chloé Abels; Damya Laoui; Eva Van Overmeire; Martin Guilliams; Elio Schouppe; Frank Tacke; Carlie J. deVries; Patrick De Baetselier; Alain Beschin

doi:10.1371/journal.ppat.1004873

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Peer-reviewed

Research Article

Ly6C^- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C⁺ Monocytes into Macrophages

Yannick Morias ,

Contributed equally to this work with: Yannick Morias, Chloé Abels

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Chloé Abels ,

Contributed equally to this work with: Yannick Morias, Chloé Abels

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Damya Laoui,

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Eva Van Overmeire,

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Martin Guilliams,

Affiliations Inflammation Research Center, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium, Laboratory of Immunoregulation and Mucosal Immunology, University Gent, Gent, Belgium
⨯
Elio Schouppe,

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Frank Tacke,

Affiliation Department of Medicine III, Rheinisch-Westfaelische Technische Hochschule (RWTH) University Hospital Aachen, Aachen, Germany
⨯
Carlie J. deVries,

Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Patrick De Baetselier,

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Alain Beschin

* E-mail: abeschin@vub.ac.be

Affiliations Myeloid Cell Immunology Laboratory, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯

Ly6C^- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C⁺ Monocytes into Macrophages

Yannick Morias,
Chloé Abels,
Damya Laoui,
Eva Van Overmeire,
Martin Guilliams,
Elio Schouppe,
Frank Tacke,
Carlie J. deVries,
Patrick De Baetselier,
Alain Beschin

Published: May 28, 2015
https://doi.org/10.1371/journal.ppat.1004873

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Monocytes
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Macrophages
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Bone marrow cells
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Cell differentiation
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Parasitic diseases
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Inflammation
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Gene expression
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