IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

Josephine M. Reynaud; Dal Young Kim; Svetlana Atasheva; Aliaksandra Rasalouskaya; James P. White; Michael S. Diamond; Scott C. Weaver; Elena I. Frolova; Ilya Frolov

doi:10.1371/journal.ppat.1004863

Loading metrics

Open Access

Peer-reviewed

Research Article

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

Josephine M. Reynaud ,

Contributed equally to this work with: Josephine M. Reynaud, Dal Young Kim

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Dal Young Kim ,

Contributed equally to this work with: Josephine M. Reynaud, Dal Young Kim

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Svetlana Atasheva,

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Aliaksandra Rasalouskaya,

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
James P. White,

Affiliation Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Michael S. Diamond,

Affiliations Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Scott C. Weaver,

Affiliations Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Elena I. Frolova,

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Ilya Frolov

* E-mail: ivfrolov@uab.edu

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

Josephine M. Reynaud,
Dal Young Kim,
Svetlana Atasheva,
Aliaksandra Rasalouskaya,
James P. White,
Michael S. Diamond,
Scott C. Weaver,
Elena I. Frolova,
Ilya Frolov

Published: April 30, 2015
https://doi.org/10.1371/journal.ppat.1004863

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
5' UTR
Is the Subject Area "5' UTR" applicable to this article?

Thanks for your feedback.
Alphaviruses
Is the Subject Area "Alphaviruses" applicable to this article?

Thanks for your feedback.
Virions
Is the Subject Area "Virions" applicable to this article?

Thanks for your feedback.
NIH 3T3 cells
Is the Subject Area "NIH 3T3 cells" applicable to this article?

Thanks for your feedback.
Protein translation
Is the Subject Area "Protein translation" applicable to this article?

Thanks for your feedback.
Vertebrates
Is the Subject Area "Vertebrates" applicable to this article?

Thanks for your feedback.
Chikungunya virus
Is the Subject Area "Chikungunya virus" applicable to this article?

Thanks for your feedback.