Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Yasir Alhamdi; Daniel R. Neill; Simon T. Abrams; Hesham A. Malak; Reham Yahya; Richard Barrett-Jolley; Guozheng Wang; Aras Kadioglu; Cheng-Hock Toh

doi:10.1371/journal.ppat.1004836

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Open Access

Peer-reviewed

Research Article

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Yasir Alhamdi,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
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Daniel R. Neill,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Simon T. Abrams,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
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Hesham A. Malak,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Reham Yahya,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Richard Barrett-Jolley,

Affiliation Department of Musculoskeletal Biology, Institute of Aging and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom
⨯
Guozheng Wang,

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Aras Kadioglu ,

* E-mail: A.kadioglu@liv.ac.uk

Affiliation Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Cheng-Hock Toh

Affiliations Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, Roald Dahl Haemostasis & Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, United Kingdom
⨯

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection

Yasir Alhamdi,
Daniel R. Neill,
Simon T. Abrams,
Hesham A. Malak,
Reham Yahya,
Richard Barrett-Jolley,
Guozheng Wang,
Aras Kadioglu,
Cheng-Hock Toh

Published: May 14, 2015
https://doi.org/10.1371/journal.ppat.1004836

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